http://localhost:8080/jspui/handle/123456789/328 2026-04-14T16:14:10Z http://localhost:8080/jspui/handle/123456789/771 Title: 5-(tert-Butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol Authors: BOUARATA, Linda Abstract: Novel 5-(tert-butyldimethylsilyloxy)-1-(2-chloro-5,8-dimethoxyquinolin-3-yl)-3-methylenepentan-1-ol (7) was prepared via allylation of 2-chloro-5,8-dimethoxyquinoline-3-carbaldehyde (6) with functionalized allylic iodide as tert-butyl-(3-(iodomethyl)but-3-enyloxy)dimethylsilane (5), in the presence of metallic indium in anhydrous DMF as solvent at ambient temperature. The structure of the synthesized compound was assigned on the basis of elemental analysis and spectral data. 2012-12-14T00:00:00Z http://localhost:8080/jspui/handle/123456789/770 Title: Sintering behavior of fluorapatite-based composites produced from natural phosphate and alumina Authors: DJOUALLAH, Samira Abstract: In this investigation, we studied the reaction-sintering between fluorapatite and alumina using natural phosphate and boehmite. The addition of alumina, resulting from the boehmite transitions, to the fluorapatite (FAp) has been carried out to obtain various composites based on FAp, yeelemite, mayenite, grossite (CA2), hibonite (CA6) and β-TCP. Several samples were prepared by varying the boehmite (AlOOH) amount to obtain six compositions which contain after sintering: 5, 10, 15, 20, 25 and 30 wt% of Al2O3. After ball-milling for 5 h, all compositions were sintered in the air for 2 h at different temperatures ranging from 1000 to 1500 °C. The reactions and phase transformations between fluorapatite and boehmite were studied and characterized by DTA/TG, XRD, FT-IR, apparent density and open porosity measurements, micro-hardness and SEM analysis. The micro-hardness and densification of the sintered body showed a marked improvement by increasing the alumina content and sintering temperature. Especially, sample containing 25% alumina exhibited the highest densification at 1400 °C (2.95 g/cm3) and excellent micro-hardness of about 6.5 ± 0.25 GPa. So the preparation of low cost composites based on fluorapatite, yeelimite and grossite from natural phosphate and alumina are feasible. 2021-02-01T00:00:00Z http://localhost:8080/jspui/handle/123456789/769 Title: Synthesis, structure characterization, spectral properties, DFT calculations, hirshfeld surface analysis, thermal stability and bioactivity of a new sulfamethoxazole zinc(II) complex Authors: HABILA, Imane Abstract: This study reports the synthesis of a new sulfamethoxazole zinc(II) coordination complex: bis(5-methyl- 3-isoxazol-2-yl sulfanilamido)-diaqua-zinc(II), C20H24N6O8S2Zn, (I). Synthesized compound has been fully characterized by single-crystal and powder X-ray diffraction, FT-IR, UV–visible absorption and NMR (1H and 13C) spectroscopy techniques. In Zn(II) coordination sphere, sulfamethoxazole behaved as monodentate ligand and coordinated via nitrogen of sulfonamide group. Complex (I) was recovered in its crystalline form and was analyzed by single-crystal X-ray diffraction technique which held orthorhombic crystal system with space group (Pnma). The molecules of (I) are linked into chains through intermolecular N–H···O, O–H···O and C–H···π non covalent interactions. The intermolecular contacts were examined using Hirshfeld Surface investigation. Furthermore, computational analysis were performed through Density Functional Theory (DFT) utilizing the mPW1PW91 basis set at the TZVP level of theory and the theoretical results were correlated with experimental data. The antimicrobial and antifungal activities of the free ligand and its synthesized Zn(II) coordination complex were evaluated using the well-diffusion method in DMSO. The microbial strains investigated include one Gram-positive, five Gram-negative and three funguses bacterial strains using the standard antibiotics “Cotrimoxazole” as positive control. 2022-03-31T00:00:00Z http://localhost:8080/jspui/handle/123456789/768 Title: A new complex of Zinc (II) with sulfamethoxazole ligand: Synthesis, crystal structure, Hirshfeld surface analysis, thermal properties, DFT calculations and antibacterial/antifungal activities Authors: HABILA, Imane Abstract: A new complex of Zinc (II), with sulfamethoxazole ligand (SMX) has been obtained at room tempera- ture by the reaction of Zinc chloride with sulfamethoxazole in ethanol solution: (5-methyl-3-isoxazol-2- yl sulfanilamido)-trichloridozinc (II), C 10 H 12 N 3 O 3 SZnCl 3 , (I) . Synthesized compound has been fully char- acterized by single-crystal X-ray diffraction (XRD), FT-IR, UV–visible absorption and NMR spectroscopy techniques and TGA analyses. The XRD analysis suggests that the crystal structure of (I) exhibits a double layers parallel to (100) plane creating cross tunnels, which are connected together via the intermolecular N-H...O and N-H...Cl hydrogen bonds to form a three- dimensional network. The intermolecular interac- tions were investigated using Hirshfeld surface analysis. The thermal behavior of (I) was also discussed using TGA which indicates that the compound is stable up to 235 °C. The DFT calculations have been per- formed by using the mPW1PW91 basis set at the TZVP level of theory and the calculated results show that the optimized geometry can well reproduce the crystal structure. Microbiological studies of this new complex with emphasis on its possible application as a novel antifungal and antibacterial agent are also performed using the well-diffusion method in DMSO. 2021-11-15T00:00:00Z